I'm sure sample to sample variation does occur in handmade cartridges - even those wound by machinery. However, I don't believe that the issue is responsible for any more inaccuracies than say any electrostatic speaker or mechanical system ( think turntable, isolation, damping, belt tightness, azimuth, P2S distance etc.)
The problem is really only when the tip is at such an extreme angle that it's nearly impossible to get a correct VTA/azimuth. Tonearms can behave differently at intense angles, as their weight properties can vary a fair bit. People have had this problem with the cheapest and most expensive cartridges. It shouldn't happen, but due to the extremely small nature of the application, it can. It is not something I'd be terribly worried about, but again if I was spendy serious money on a cartridge then I'd want to know that I could return it in the occurrence that it is essentially will negate the good qualities by causing imbalances.