Knut Skogrand uses AWG12 UPOCC copper in his ultra expensive cables. They are getting rave reviews. The skin effect is obviously no problem.
As you know, silver has a huge advantage over copper since you do not require an airtight insulation to avoid oxidation, and you are free to experiment with eg. organic cotton or silk.
Yes, skin effect is a problem with 12g wire but if you're using it for a tone control then it's an asset. It depends on how you view cables and what you want them to do.
However, the largest issue with 12g wire is it is not designed to be bent repeatedly, which means it's an exceptionally poor and I would also say, incompetent and unethical choice of wire to use for cables. The wire will crack first, which will lead to the sound quality going downhill over time before it fails completely. If it's used for AC power it may lead to a fire and imo the cable will be 100% at fault if this occurs.
I've made several prototype headphone cable and it's very interesting how even wire much smaller than 12g will crack.
This is the 2nd time I've seen 12g solid core wire being used for expensive cables in the last month or so, and I want to emphasize to the folks here just how bad and thoughtless it is to offer these cables. And yes, I've seen it for power cables and I can't understand how the designer could be so ignorant. Furthermore, the purchaser or such cables is also risking their own safety as well as their family's safety. I'm not exaggerating this.
It's really too bad there is so much misinformation out there and also too bad that consumers are so overwhelmed with information they don't know who or what to believe. This leaves room for people to offer cables for sale that are very poorly designed, and when someone like myself, who is an engineer and also specializes in manufacturing and design for manufacturing/assembly to see these things and not be taken seriously. I posted that 12g solid-core power cables were dangerous on said thread and was ignored by everyone in that thread. I sincerely hope you never run into issues with this and your cable doesn't start a fire, but to ignore this issue is incomprehensible to me. Is better sound worth it? Seems crazy to me.
As far as silver not requiring airtight insulation, this is 100% false. The wire will corrode over time and the material next to the conductor will has a major effect on sound quality, this is why teflon is better vs PVC and why plated wire sounds much different vs unplated wire even though the plating is very thin vs the wire.
I also see lots of cable companies offering cables that will corrode over time and IMO this is also inexcusable.