Of course there is. This field is not remotely limited to entertainment audio. The principals of digitizing samples is used in all manner of electronic technology. If there is a flaw in it and it can be fixed, it can lead to many improvements. The front end of your mobile phone for example converts the RF signals into digital and does the decoding in that domain. If there is a fault in digitizing samples, fixing that would improve signal to noise ratio and have huge advantage. Practically every scope we use to instrument signals is also digital. Again, if there are artifacts, they show up there and removing it again will have immense value. On and on.
So I ask again, if there is a problem with sampling audio into digital domain, why is it that it is not a focus of hundreds of thousands of smart engineers around the world?
The arrow as I mentioned at the outset points back to us. While we talk about these "distortions" being readily audible to us, we have not remotely managed to make even a vague case for it. A thousand anecdotal observations doesn't make for any case. As I said, if we want this to be a problem that is worked on, we need to demonstrate it reliably and without bias. We are both unwilling and unable to do that. And that becomes our failings, not anyone else's.
Man, I am working hard to make friends in this new year, aren't I?