The thing that acousticians and and everyone in the industry preaches to us is symmetry in a room. You can certainly see that in pictures. If you don't have this to begin with, then everything else is just a band-aid.
And about recording/mixing in a room... the reason you listen in the nearfield to be begin with is to take the room out of the equation!
I would agree with this. Although I recently was made more aware of another factor, this from an a'phile friend, and that is the volume of the room.
My room, which has smaller wall dimensions, has due to its high vaulted ceiling, a decent volume. This factor certainly seems to work greatly in its favor. Listening in the near field certainly does minimize the wall interactions.
I used to believe that optimizing a small room was much more difficult than optimizing a large room...I'm not so sure anymore.