I think Mitsubishi is one of the major companies touting 6N or better, Acrolink has posted exact content of impurities, etc. The Ohno Continuous Casting Process patents describe the casting of 6N purity metals in inert gas atmosphere, etc. so I think that's proven, but once exposed to oxygen it will immediately corrode where exposed, but the rest of the insulated wire should be sealed from the atmosphere. This is also why I question cables made with textile dielectrics that allow exposure to air, it's a cable that will corrode over time and probably sounds worse and worse as time goes by... But imo purity makes a big difference, and 6N UPOCC metals are several percent more conductive on the IACS scale, this is an easily measurable difference and the difference in sound quality when used in audio systems is very obvious.
I think where high purity is often thought of as impossible is in the context of traditionally drawn wire, where the metal is repeatedly drawn through dies without necessarily being protected from oxygen by an inert gas shield.
High purity, 6N+, has also been impossible to confirm with conventional measurements but I believe the latest mass spectronomy techniques can indeed measure past 6N now.