I understand exactly where you are right now as it was where I was a couple of years ago.
First, I decided to keep my reference (mostly because I love how they sound) my Odeon LA Boheme speakers + Aries Cerat and have a second system that does the business of keeping me a hobbyist.
The high sensitity speaker world is interesting because there are horn and non-horn solutions (at least up to about 100db/watt). Just to break down a few archetypes that you could choose from:
Full range driver in a backloaded horn: Pnoe is probably the ultimate expression of this concept. The strength is the coherence from the mid-bass up but the weakness is usually the bass and it is only as good as the driver you can afford (and the sky seems to be the limit). To really get excellent sound this is very expensive way to go.
Fullrange driver in a TQWT cabinet: Similar to a backloaded horn but better bass for a given cabinet size. Cube Audio and Supravox use this to good effect. Modest size but good bass and high sensitivity allows moderate power.
Augmented Full range driver (or wideband) in backloaded horn or TQWT: Use of a widebander with tweeter only coming in the top octaves. Bass is still and issue but less so with a modest sized TQWT. A commercial example of this was my Odeon, old Dyanvox (now Dynamikks) and Cessaro Wagner (which uses the same Supravox I am using). Great for rooms up to about 30sqm.
Fullrange driver in front horn with woofer system: This is what Bill has gone with and you see this also with Oris horns and the speaker from Totaldac. The woofer system can be either a large woofer in a vented box, a dipole array, sealed servo system, etc. If bass is active, then the fullrange in the front horn can be very high sensitivity, or if passive then multiple woofers can also give a good sensitivity.
Multi-way TQWT: This is what I have chosen to go with as it balances size, sensitivity, bass performance and relative ease of construction. My Odeons are a two-way expression of this as are my experimental speakers (for now). In DTQWT they become a three-way with more bass power. With this you go with a high sensitivty non-horn mid/bass (I have chosen the Supravox 215-2000 you could probably make the mid a horn as well) and a horn that goes as low as 500-600 hz, which is still a managable size. If you go larger then you need a tweeter as well to make a 4-way. What I have found is that you don't get cabinet sound from such a design and at around 100db/watt it is plenty sensitive to use with single digit amps. The best known commercial example is the Horning Hybrid Eufrodite, which is a DTQWT but without horn highs (its main weakness I think). I have found that even in two-way configuration it handles big music quite well as the pro drivers in the horn are not really working that hard (they are designed for 125db all day long). I find the bass preferrable to the usual big vented box although if you have the space a dipole bass (like Bill's design...I think) works great too.
Multi-way backloaded horn: A prime example of this is Aries Cerat Symphonia, where the backloaded horn is only doing the bass to lower mids and front loaded horns take over after that. The Living Voice Vox Olympian would also fit here. Can be the ultimate speakers, diffcult to build and tune...I would not tackle this unless you really know what you are doing...and maybe not even then...at least not more than 4-way. Most companies cannot build a good two-way...the problem is exponential. Big rooms needed
Multi-way horn and separate active or passive woofer system. Avantgarde and Cessaro are big players here. IMO, this is very difficult to achieve coherence and balance. Maybe Kodomo has done so but this requires serious dedication like the category above. Big rooms needed. Horns Universum kind of fits here too and is a relatively simple three-way (I would not go more than this if you truly want coherence). Avantgarde Duo Mezzo is an interesting bridge.
Multi-way front loaded horn: Klipschorns, JBL Hartsfields and Paragon fit into this category. Also a difficult proposition and large but can sound as phenomenal as the Multi-way backloaded horn (Hartfields are still one of the best speakers if a tweeter is added).
Multi-way (2 or more) with FLH mid/high (compression driver or can be a cone) and large woofer (or woofers) in a vented or vented+FLH box. Examples abound from JBL, Altec and other studio monitor and theater speaker companies. Acapella and Odeon would also fall into this category. This is Ked's choice for the moment (at least the large format Altec style solution) and is relatively straightforward to implement. Get a mid/high horn that can go up to close to 20Khz (there are several good choices on the market now as you know) and there are a ton of pro woofers that also sound very good in the mids and have endless power handling. Something from Acoustic Elegance would be my first choice for woofers in the category but probably 2 in parallel to get the SPL up a bit closer to 100db. Classic woofers would also work well if you can find them in good condition (or Great PLains Audio). There are a ton of DIY projects like this on the web as well. If you have the real estate then FLH on the woofer box to give a bit of horn gain on the lower mids/upper bass.
Coaxial driver with woofer augmentation. Live Act Audio, Urei 813 (classic studio monitor based on the Altec 604), Dynamikks. Very good coherence and relatively easy to implement. Large coax + large woofer will give high sensitivity and work great in large rooms. Easily driven by 20+ watt SET. Woofer alignment can be sealed, vented or TQWT and all work well if done right.
I know of very few active analog crossovers good enough (Accuphase F25 is one of them or maybe some tube ones...like Marchand) for such revealing systems. Digital crossovers in hardware (or software) work well but do not buy one with built-in DACs unless it is just for design. Digital in/Digital out seems to be totally transparent (perhaps need some jitter reduction...I use Monarchy Audio DIP on my system) but then you need two good/great DACs and multi-channel amplification (true for all active setups). Passive is, well, a pain to get right.
If you want a big music system then it will have to be at least 2-way and probably 3-way with a large format CD and a small tweeter and one or more large woofers. The system I will ultimately settle on will be two and a half way where the mid also contributes to the bass in a DTQWT with two 10-12 inch woofers on the backside, my Supravox mid and then a horn covering from 1khz and up (or I might try an even larger horn and driver and go from 500hz or so and then add supertweeter...right now I am finding the 1Kz-20Khz with CD a good solution). the final speaker will stand about 1.4 meters but not be too wide...so still room acceptable for WAF that is decent. IMO, this kind of design is hard to beat in a <30 sqm room.