Sure.
The Python ZiTron has a fuller sound from bottom to top. And non-euphonic (like the previous generation (non Zi-Tron ) Python.
The Alpha HC (ZiTron) is to my ears, leaner in the upper bass and lower midrange unless you have components that have compensated for this. (Current Shunyata cords: Cobra ZiTron, Alpha (not HC), Python ZiTron, Sigma NR ZiTron.)
The standard wisdom is to go for the Alpha HC, but after having it for 3 years, I finally couldn't shake the sound of "leanness", (think of it as "analytical" and with lesser "musicality," meaning "the way actual live instruments sound" in my living room, basement OR at Carnegie Hall/The Metropolitan Opera/Avery Fisher (now David B. Geffen Hall), all in New York; Louise Davies (San Francisco) - in comparison to the Python ZiTron, which I love. Can't go wrong there.
I'm sure the Alpha HC noise floor is lower, but it didn't impress me that much. It sounds a bit sterile to my ears Keep in mind, I've owned Shunyata since 2003, and have had every single iteration and listened to nearly everything they have made. Bought Sigmas (both versions: the one preceding the NR (the NR is considerably better in my opinion that the preceding Sigma cable, whose designation I do not recall). Listened to the Alpha NR, bought the Delta (sold it: don't go to a non-ZiTron once you've owned ZiTron. You'll notice it immediately and if you're anything like me, will be disappointed. It's a good cord, but once you hit ZiTron, you'll have to stay 'ZiTron-ed" for life. A half-deaf person (oh, wait, that's me!) can hear it, so unless your hearing's deteriorated, you, too, will hear it.
My favorite is the Sigma NR, which is breathtaking - and THAT (!) on a modest system. Wasn't as keen on the Alpha NR, much to my dismay. Shunyata disagrees with my summation of the Alpha (NR version), but others have heard this too (somewhere in a thread on here from 3 years ago), but I have to report what I heard in my system.