Dave, it's almost 2016, these days it's not difficult or expensive to build a balanced interconnect with 3 zeros between the decimal point and the first significant figure in the THD measurement. At that level it doesn't matter what harmonic the distortion is.
To use unbalanced interconnects in a high-end system is an oxymoron.
That's simply not the case, and your first sentence makes no sense to me, I already said it's not about the cable, it about balanced systems as a whole. Lots of high end systems and components are single ended only and many experienced audio designers prefer single ended home audio systems. In a home environment the common mode noise rejection of balanced systems simply isn't necessary to eliminate interference and provide a low noise floor. Balanced components need two of everything, it's more complicated and expensive for questionable gains. The 2nd harmonic distortion cancellation inherent to balanced systems (that's SYSTEM, not cable!) often makes the sound more mechanical, dry and less musical. I can provide tons of examples of extremely high quality single ended components, like every SET amp in existence for one, tube preamps without a single XLR jack in them, etc...