In reality the output level has significance in a pro world, where all such things are standartized, but not in the consumer world where head preamps, phono stages, CD players, etc are connected to line preamps, that always have VOLUME control.
So whether your head preamp produces +4dB at 320nWb, or 0dB is not important, because you still set your listening volume by your ears.
As long as your output is withing some reasonable range, you are OK.
If you bring home ten randomly selected audio sources you will get ten very different levels. Some CD's will output up to 10V, many phono stages much, much less.
That is why some preamps have Relative Volume function, that allows you to equalize the volumes when switching the sources. I have it on mine... although I rarely use it myself
So I would not get stuck on some "standard" level, unless you are building a studio. Every preamp has its own most comfortable volume control range, say, it is between 6 and 10 o'clock, or between 60 and 100 display counts... as long as your head preamp works in that range you are fine.
Some +4dB calibrated sources will force you to set your volume too low, which will damage your sound quality. We had some customers report using super-low settings, and that is not good for sound.
This is specific to playback device for home audio, the recording chain is a totally separate question, and there I wish more producers were using PPM meters, but that is entirely different subject.
Whether doing calibration is going to help you avoid an overload - it shouldn't, if your device is properly designed.