The farther you pull into the room the more some frequencies will sound like a reflection (ambiance). But at some point you will be time aligned such that it's close but not close enough to some frequencies sounding like they have the same source.
You have 4.3ft of smudge room between your bass towers and m/t towers at 250hz, where they'll sound like the same source. That will allow you to play with positioning, and straight forward facing may not be what you prefer. Finding the optimal placement will reduce the need for traps etc. The real trick is having the ear for phase.
By a similar principle you need to exceed 2.15ft in order to overcome gain in any frequency range produced by the m/t towers. (gain that offsets the balance). This is because that's the distance for the lowest frequency played by the m/t tower that reflects off the back wall forward (4.3/2). It's best to go a bit over or it'll sound sorta muddy, so 3-4ft is min to start with. If the lowest points of the ribbon are not somewhat directed then even at say 4ft, it's got 7ft to travel so it won't interfere.
The Aesthetix Io Eclipse has single and balanced outputs, why not just run cheap XLR's to the bass towers? Just order some from Blue Jeans Cable. It is not like you are going to hear a difference in the case of bass only; and if there is something is faulty. They offer a very low capacitance cable that is ideal for bass.
Do you have windows in the room?