It depends on people mains, that can be very variable and amplifier type. Yesterday I measured the mains impedance in my future location - less than 50 milliohms, with less than .5% THD. Probably I will not need a regenerator.
However some friends of mine could benefit from them , as their mains was instable and had high THD. As they say, nowadays the system always sounds like weekends at late night.
If, as many people have, we have an amplifier that is always in class A mode, what is the problem of using a proper regenerator?