The argument that single-ended should not be used for long interconnect runs because you have a small amount of voltage drop seems silly since one can simply raise a volume control a litte bit to compensate.
Don gave the precise and exact answer. But to expand, the drop in voltage we worry about here is in the shield of the RCA/unbalanced connection. That drop in voltage will by definition cause a flow of current (it is like titling a full cup of water). Since the source of that voltage is mains, the shield is now dancing up and down with the frequency and harmonics of mains.
The above by itself is not a problem in differential/balanced connections. In unbalanced however, the signal, the center pin of RCA, is in reference to the shield. If for example you output nothing and the shield is dancing up and down, the receiver "hears" the dancing up and down as the signal. Hence the reason you hear hum or buzz (harmonics of mains).
In differential interconnects, there are two wires independent of the shield that carry the audio signal. As a result they are immune to vagaries of voltage drop in the shield, or differential in voltage between the chassis of two pieces of audio equipment (topic of this thread). It is absolutely superior to using unbalanced connection.
To give you a specific sense of this in an example, simple math shows that enough current flows in the shield of of an unbalanced connection can cause your signal to noise ratio to drop to poultry 70 db. That is just 12 bits of resolution! The same exact system/situation over balanced connection will boost the signal to noise ratio to whopping 130 db! Well beyond 96 db of 16-bit CD for example and beyond anything we can reproduce (analog or digital).
Balanced interconnects are trivially implemented using solid state electronics. The cost is in the noise in class of product we are discussing, pun intended
. Tube amp manufacturers don't want to use this solution likely because then the whole path is not tube. So it has been turned into a feature: "single ended sounds better." Well, it doesn't if you don't want your signal to be accompanied with tons of mains signal mixed in it.
Members here go to heaven and hell to try to deal with "grounding issues." Yet they go and use single ended interconnects where it nicely carries and dumps mains related distortion into their audio path! It makes no sense.
RCA connections were invented to interconnect equipment in the same box. Never was it intended to go many feet to monoblock amps by speakers which is so common here.
Thankfully we are deaf as a stomp when it comes to low frequencies so that is the reason there is not as large of a cry as it should be. Still, if you sweat all the details, and your RCs are going the distance, you need to use balanced interconnects if you have any hope of staying true to the source music.