each audiophile mains system and audio system is particular enough to kill any hope of generalization. Experimentation and basic electrical common sense are the only rules.
+1
From personal experimentation I know that the PS Audio regenerator sounds different than an Equi-Tech isolation transformer. I suspect a Stromtank sounds different than a PS Audio regenerator or an Equi-Tech.
So all of these devices make our systems sound different. The question is: is different subjectively better?
In my new system I decided not to go down this road at all, and I'm not using any of these devices.
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