You definitely have to be careful w tweaks, in that you don't get one advantage at the expense of a negative somewhere else.
My first experience of that was installing the Burmester 948 conditioner, which upped the ante on detail and noise reduction, but smeared dynamics.
Entreq increased air and soundstaging in my old room, but much less dramatic in my current one.
Shun Mooks dramatically beefed up texture and bass solidity in my old room, proved to be slow and monotone in my current room.
IsoAcoustics Gaia footers under my Zus were great for bass definition and imaging, but slowed timing and leading edge.
All of these except the Entreq are no more in my system.
Those tweaks that have cumulatively enhanced tone, timbre, texture, solidity, realism, transparency and neutrality, are all staying. They've proved to be wholly positive, not negative in the least, and critically allow lps and cds to sound totally different in terms of tonal discrimination from one album to the next.
Including Sablon cables, Stacore and Symposium isolation, RevOPods spkr footers, Westwick balanced power, Oyaides dedicated lines, Furutech sockets, SR fuses and GIK acoustic panels.
For me the critical thing is, if there is an improvement e.g. enhancing bass, is it counterbalanced elsewhere e.g. slower dynamics. And is there any homogeneity imposed from one record to the next. If this is the case, no matter how attractive the improvement, it's better to pass.
Never was this so noticeable in the Gaias v RevOPods footers trial I did last month. The Gaias were really compelling out of the box. Bass was superlative. Until it became apparent that every record seemed to have the same bass player playing the same bass guitar. Switching to the RevOPods was a "cooler" experience tonally in the low end, but now you could easily pick out Jack Bruce or Geddy Lee or John Entwistle etc. And bedding the RevOPods in has allowed the bass to bloom as per the Gais, but w no imposing of monotone character.
That's my detailed take on "to tweak or not to tweak"