Isn't the punchline that:
*measurements, as we know them, don't adequately describe or predict what we hear from various components, let alone how they will sound in combination with each other;
*even if a given manufacturer strives to make a neutral, full bandwidth device, it will inevitably have some sonic signature; that signature may be complemented with matching equipment from the same manufacturer, or may be highlighted, for better or worse, with equipment from another manufacturer;
*that 'synergy' as we are using the term here, is an attempt to match the sonic characteristics of the different parts of a system to make it sound 'better' (whatever your definition of 'better' is- more lifelike, truer to the original recording, etc.) overall, as a system?
I am not attempting to justify 'fixing' a "bright"-sounding amp by adding a "soft" or "dull"- sounding preamp. But, I can almost guarantee that picking a system of "bests" based on specs or reviewer accolades, is not going to sound as 'good' (see 'better,'above) as a system that is assembled as a system. And if that is art, not science, I guess we are still living in the dark ages. But, I don't think it is imaginary, or voodoo. I can't get the full measure of a piece of equipment unless I listen to it in a controlled setting, knowing the variables. And if it is for my home system, I ultimately have to listen to it in that system.
If I understood Ethan's post that started this thread, I took it to mean that he was speaking of an ideal. That is, there 'should' be no difference in the sound of equipment designed to be neutral in the first place. But that has not been my experience.