Absolutely true about rooms. Couple a pair of speakers to a raised wood floor. Couple the same pair of speakers to a concrete slab. They will sound different. And it will be measurable.
And measuring could be very useful. Most people in America have suspended wood subflooring, even if there is just carpet on top. Measure coupling to enough rooms with such floors and a patter might emerge. One might get a very good idea of what coupling to such a floor will do to FR. My guess is there are some repeatable patterns. I think it would be very useful to know what they are, particularly to speaker designers.
Or maybe not. Or maybe it's just a lot more fun to play with spikes and blocks and blue tack until you hear what you like. Different strokes and all that.
Tim